Acetyl chloride → Benzoic acid, 3-methoxy-4-methyl-, methyl ester

関与物質

反応手順

A solution of 3-methoxy-4-methylbenzoic acid (6.0 g) in methanol (120 ml) was treated with acetyl chloride (6 ml) and stirred for 36 hours. The solution was evaporated. The residue was dissolved in methanol (100 ml) and the solution evaporated. This procedure was repeated to give methyl 3-methoxy-4-methylbenzoate (6.34 g, 98%) as a colorless oil; NMR (80 MHz, CDCl3): 2.2(s, 3H, CH3), 3.9(2s, 6H, 2×OCH3), 7.1(d, 1H), 7.5(m, 2H).

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