Hydrochloric Acid → HCID 19869692、化合物

HRID 330298ノート

反応式

HRID 330298 の反応式
[N:1]1[C:2]([C:13]([O:15]CC)=O)=[CH:3][N:4]2[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.[BH4-].[Li+].Cl.[C:21](=O)(O)[O-:22].[Na+]>CCO>[CH3:21][O:22][C:10]1[CH:11]=[CH:12][C:7]2[S:6][C:5]3=[N:1][C:2]([CH2:13][OH:15])=[CH:3][N:4]3[C:8]=2[CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 1480574ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylateHCID 4148881Lithium borohydride

生成物 1

HCID 19869692HCID 19869692、化合物収率 96.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of 4.0 g of ethyl imidazo[2,1-b]benzothiazole-2-carboxylate in dry T.H.F. was stirred with 1.5 g of lithium borohydride for 48 hours at room temperature under dry nitrogen. The mixture was treated with an excess of 2N hydrochloric acid and warmed to 50° C. for 2 hours to decompose the complex. The mixture was made alkaline with aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness under reduced pressure to obtain 3.27 g (96.4% yield) of 6-methoxy-imidazo[2,1-b]benzothiazole-2-methanol as a colorless solid melting at 189° to 190° C. (EtOH).

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe extracts were dried over magnesium sulfate
  3. customevaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-6fe6b48c08d14785a556bfed9cbc3b5a
出典データセット
uspto-grants-1990_01
特許番号
US04895863

反応ノート

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