Water → HCID 14699389、化合物

HRID 330306ノート

反応式

HRID 330306 の反応式
[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Cl)[CH2:2][CH3:3].[C-:13]#[N:14].[Na+].O.CCOCC>CS(C)=O>[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][C:13]#[N:14])[CH2:2][CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 8929Sodium CyanideHCID 19869706HCID 19869706、化合物

生成物 1

HCID 14699389HCID 14699389、化合物収率 54.1%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
50 °C

実験手順

A 2 liter flask was charged with 367 grams (1.90 moles, 1.0 ec.) of crude 2-propoxybenzyl chloride in 700 ml of DMSO. The reaction is cooled by a water bath and 102 grams of sodium cyanide (2.09 moles, 1.1 eq.) was added and allowed to warm to 50° C. After the exotherm was complete, the reaction was stirred at room temperature overnight then worked up with water, dilute acid and ether. Removal of the solvent was followed by distillation (120°-150° C. at 1 mm) and gave 180 grams (54% Yield) of a light yellow oil.

後処理

  1. temperatureThe reaction is cooled by a water bath
  2. customRemoval of the solvent
  3. distillationwas followed by distillation (120°-150° C. at 1 mm)

出典と根拠

ORDレコード
ord-e3c61b1b45b74504a49f239cd66a41d8
出典データセット
uspto-grants-1990_01
特許番号
US04895865

反応ノート

読み込み中…