N-[[(E)-but-2-enylidene]amino]pyridine-3-carboxamide → (5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone
反応式
[C:1]([NH:9][N:10]=[CH:11]/[CH:12]=[CH:13]/[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1>C1(C2C=CC=CC=2)C=CC=CC=1.CCOCC>[C:1]([N:9]1[CH:13]([CH3:14])[CH2:12][CH:11]=[N:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1参加物
3
実験手順
Nineteen grams of this hydrazone was suspended in 50 ml of biphenyl ether, followed by stirring at 200°-220° C. (bath temperature) for 3 hours. After cooling, the reaction liquid was purified by silica gel chromatography (CHCl3 :MeOH=100:1). Thus there was obtained 8.0 g of 1-nicotinoyl-5-methyl-2-pyrazoline in the form of an oil (bp. 143°-145° C./0.3 mmHg). The yield was 42.1%.
後処理
- temperatureAfter cooling
- customthe reaction liquid
- customwas purified by silica gel chromatography (CHCl3 :MeOH=100:1)
出典と根拠
- ORDレコード
- ord-472ef001f2dc40c8aedb26b35efe49aa
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04895947
反応ノート
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