Methyl 2-chloromethylbenzoate → S-(2-Methoxycarbonylbenzyl)isothiourea.hydrochloride
反応式
[Cl:1][CH2:2][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[NH2:13][C:14]([NH2:16])=[S:15]>C(O)C>[CH3:8][O:7][C:5]([C:4]1[CH:9]=[CH:10][CH:11]=[CH:12][C:3]=1[CH2:2][S:15][C:14](=[NH:13])[NH2:16])=[O:6].[ClH:1]参加物
4
実験手順
A solution of 196 g of methyl 2-chloromethylbenzoate and 83.7 g of thiourea in 500 ml of ethanol is refluxed for 4 hours. The reaction solution is concentrated under reduced pressure and to the resulting residue is added 300 ml of isopropylalcohol. The precipitated crystals are collected by filtration and dried to give 112.8 g of the title compound.
後処理
- concentrationThe reaction solution is concentrated under reduced pressure and to the resulting residue
- additionis added 300 ml of isopropylalcohol
- filtrationThe precipitated crystals are collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-292e1c87e4da4ab985e86ae03a32c2ab
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04897105
反応ノート
読み込み中…