関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Beta-Nitrostyrene | HCID 7626 | 37% |
反応手順
Benzaldehyde (10.0 g, 94.2 mmol) and nitromethane (5.1 mL, 94.2 mmol) were dissolved in MeOH, the solution was cooled to -18° C., and NaOH (3.9 g, 98.9 mmol) in aqueous solution (80 mL) was added while maintaining the temperature below -10° C. The mixture was stirred at 0° C. for 2 hours, then stored at 5° C. overnight. The solution was then poured into stirring acid (200 mL conc. HCl/300 mL H2O). The precipitate was collected, washed, and recrystallized from EtOH to afford the title compound as light orange needles (5.15 g, 37%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05733912 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-e4c5a915e9a24293aae0af7d3e5b3bcb |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
