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Benzenesulfonyl chloride → 2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | 5-Ethylthio pyrrolidin-2-one | HCID 19868705 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)- | HCID 3078171 | 65.7% |
反応手順
To 3.1 g of 5-ethylthio pyrrolidin-2-one in 130 cm3 of tetrahydrofuran there is added at -65° C., 14.2 cm3 of a 1.6M solution of butyllithium in hexane. After 20 minutes, there is added 3.77 g of benzenesulphonyl chloride in 15 cm3 of tetrahydrofuran. After allowing to return to ambient temperature and concentrating to dryness under reduced pressure, 4 g of the expected product is obtained. m.p. 100°-113° C., crystallized from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04897414 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-8d118de13743442f945cc27487e6410c |
| 出典メモ | uspto-grants-1990_01 |