Dimethyl Sulfoxide → 1-Naphthaleneacetonitrile, 3-methyl-

HRID 330522ノート

反応式

HRID 330522 の反応式
[C-:1]#[N:2].[K+].BrC[C:6]1[C:15]([CH3:16])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1.[CH3:17]S(C)=O>O>[CH3:16][C:15]1[CH:6]=[C:7]([CH2:17][C:1]#[N:2])[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 9032Potassium CyanideHCID 27530932-(Bromomethyl)-3-methylnaphthalene

生成物 1

HCID 703577721-Naphthaleneacetonitrile, 3-methyl-収率 81%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

KCN (1.81 g, 27.85 mmol) was added to a solution of 2-bromomethyl-3-methylnaphthalene (5.95 g, 25.32 mmol) in 150 mL of DMSO at room temperature. The resulting mixture was stirred 1 hour, diluted with water (175 mL) and stirred another 15 minutes. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to give the desired product (3.71 g g, 81%) of sufficient purity for use in the subsequent reaction.

後処理

  1. stirringstirred another 15 minutes
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-bf3cda173b29432bae3c27bf397bbc7f
出典データセット
uspto-grants-1990_01
特許番号
US04897405

反応ノート

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