Sodium Methoxide → 1,3-Propanediol, 2-[(2-amino-6-chloro-9H-purin-9-yl)methoxy]-

HRID 330589ノート

反応式

HRID 330589 の反応式
C([O:4][CH2:5][CH:6]([O:12][CH2:13][N:14]1[CH:22]=[N:21][C:20]2[C:15]1=[N:16][C:17]([NH2:24])=[N:18][C:19]=2[Cl:23])[CH2:7][O:8]C(=O)C)(=O)C.C[O-].[Na+]>CO>[OH:4][CH2:5][CH:6]([O:12][CH2:13][N:14]1[CH:22]=[N:21][C:20]2[C:15]1=[N:16][C:17]([NH2:24])=[N:18][C:19]=2[Cl:23])[CH2:7][OH:8]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 137128349-(1,3-Diacetoxy-2-propoxymethyl)-2-amino-6-chloropurine

生成物 1

HCID 110766071,3-Propanediol, 2-[(2-amino-6-chloro-9H-purin-9-yl)methoxy]-

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 781 mg (2.18 mmoles) of 9-(1,3-diacetoxy-2-propoxymethyl)-2-amino-6-chloropurine in 22 ml of methanol was treated with 109 mmoles (5 mole percent) of freshly prepared sodium methoxide. Within ten minutes the stirred solution became cloudy and the product precipitated gradually in the course of forty-five minutes. The product was isolated by filtration, washed with 10 ml of water and dried in vacuo over P2O5 yielding 507 mg of pure product. A 200 MHz nmr spectrum in d6DMSO was fully in accord with the structure.

後処理

  1. waitWithin ten minutes the stirred solution became
  2. customcloudy and the product precipitated gradually in the course of forty-five minutes
  3. customThe product was isolated by filtration
  4. washwashed with 10 ml of water
  5. dry with materialdried in vacuo over P2O5 yielding 507 mg of pure product

出典と根拠

ORDレコード
ord-6eec0f82ce6c4a6da11d513fd92f9d38
出典データセット
uspto-grants-1990_01
特許番号
US04897479

反応ノート

読み込み中…