関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Acetone Cyanohydrin | HCID 6406 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1,7-Dichloro-heptan-4-one | HCID 246749 | — |
| 生成物 | hexahydro-1H-pyrrolizine-7a-carbonitrile | HCID 11029899 | 89% |
反応手順
To a solution of aceton cyanohydrin (2.3 g, 27 mmol) saturated with ammonia, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 48 hours at 20° C. under ammonia gas atmosphere. To the reaction mixture, 0.1N-NaOH was added to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.33 g of the desired compound (Yield: 89%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04897495 |
|---|
| 出典データセット | uspto-grants-1990_01 |
|---|
| ORD ID | ord-a85465a5215648fdaf2a095d239f17e5 |
|---|
| 出典メモ | uspto-grants-1990_01 |
|---|
