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Naphthalene → Duloxetine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Naphthalene | HCID 931 | — |
| 反応物 | 3-(N-Methylamino)-1-(2-thienyl)-1-propanol, (-)- | HCID 10095047 | — |
| 生成物 | Duloxetine | HCID 60835 | — |
反応手順
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877475B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-22aaffe062774d3e82cefa2a869d2bda |
| 出典メモ | uspto-grants-2014_11 |