Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide

HRID 330782

反応式

HRID 330782 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][C:10]=1[OH:16]>C(O)(=O)C>[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[CH:11][C:10]=1[OH:16]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 806765-Amino-2-chlorophenol

生成物 1

HCID 14122483N-(4-Chloro-3-hydroxyphenyl)acetamide収率 93%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

後処理

  1. temperaturethe reaction was refluxed for 5 mins
  2. filtrationIt was filtered off
  3. washwashed with water (10 mL)
  4. customdried

出典と根拠

ORDレコード
ord-b36c980b138d4933833e7cd7a8fdd153
出典データセット
uspto-grants-2014_11
特許番号
US08877752B2

関連ノート

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