Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide
反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][C:10]=1[OH:16]>C(O)(=O)C>[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[CH:11][C:10]=1[OH:16]参加物
4
実験手順
Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.
後処理
- temperaturethe reaction was refluxed for 5 mins
- filtrationIt was filtered off
- washwashed with water (10 mL)
- customdried
出典と根拠
- ORDレコード
- ord-b36c980b138d4933833e7cd7a8fdd153
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877752B2
反応ノート
読み込み中…