Hydrochloric Acid → 2-Amino-4-bromo-5-fluorobenzoic acid hydrochloride
反応式
[Br:1][C:2]1[C:10]([F:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N+:12]([O-])=O)[CH:3]=1.Cl.[Sn](Cl)[Cl:17]>O>[ClH:17].[NH2:12][C:4]1[CH:3]=[C:2]([Br:1])[C:10]([F:11])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]参加物
5
反応条件
- 温度
- 90 °C
実験手順
To a mixture of 4-bromo-5-fluoro-2-nitrobenzoic acid (10 g, 37.9 mmol) and HCl (70 mL, 852 mmol) in water (70 mL) was added tin(II) chloride (21.55 g, 114 mmol) and the mixture was then heated at 90° C. for 3 hours. After cooling to RT, the formed precipitate was filtered, washed with water and collected to give title compound (8.51 g). LCMS (A): m/z [(M−HCl)+H]+ 234/236, C7H5BrFNO2.HCl requires 269/271 (acidic).
後処理
- temperatureAfter cooling to RT
- filtrationthe formed precipitate was filtered
- washwashed with water
- customcollected
出典と根拠
- ORDレコード
- ord-05bc856972c04e4f88b6129307b3a6a3
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877742B2
反応ノート
読み込み中…