Hydrochloric Acid → 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

HRID 331218ノート

反応式

HRID 331218 の反応式
FC1C=CC=C2C=1CCC2=O.[F:12][C:13]1([N:28]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[NH:30][C:29]2=[O:37])[CH2:18][CH2:17][N:16]([CH:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]2)[CH2:15][CH2:14]1.[ClH:38].Cl.C(OCC)(=O)C>>[ClH:38].[F:12][C:13]1([N:28]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[NH:30][C:29]2=[O:37])[CH2:18][CH2:17][N:16]([CH:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]2)[CH2:15][CH2:14]1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 121749864-Fluoro-1-indanoneHCID 21866389Hydrogen chloride-ethyl acetateHCID 687013111-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one

生成物 1

HCID 687013101-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

実験手順

In the same manner as in Example 1 and using 4-fluoro-1-indanone, 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a brown solid.

後処理

  1. customwas synthesized

出典と根拠

ORDレコード
ord-0077fe4cb168461a9abbb4d6f050a39b
出典データセット
uspto-grants-2014_11
特許番号
US08877779B2

反応ノート

読み込み中…