Methanesulfonyl chloride → 2-(2-Fluorophenyl)ethyl methanesulfonate
反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13]>C(N(CC)CC)C.C(Cl)Cl>[CH3:11][S:12]([O:6][CH2:5][CH2:4][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])(=[O:14])=[O:13]参加物
5
実験手順
To a solution of 2-fluorophenethylalcohol (25.0 g) in triethylamine (37.5 ml) and methylene chloride (250 ml) was added dropwise methanesulfonyl chloride (16.7 ml) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was warmed to room temperature, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 2-(2-fluorophenyl)ethyl methanesulfonate.
後処理
- temperaturecooling
- washwashed with water and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c1a992d32f7e4db4abea21507bf12076
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877779B2
反応ノート
読み込み中…