Hydrochloric Acid → 6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

HRID 331266ノート

反応式

HRID 331266 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:3][CH2:2]1.[ClH:32].C(OCC)C>C(Cl)Cl>[ClH:32].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 509405096-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one

生成物 1

HCID 703126206-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one (500 mg, 1.21 mmol) obtained in Step 7 was placed into a flask and dissolved in CH2Cl2 (4.0 mL). To the resulting solution was added 1.0M HCl in diethyl ether (1.21 mL, 1 eq). The solvents were removed by rotary evaporation under reduced pressure to give the desired product in quantitative yield.

後処理

  1. customThe solvents were removed by rotary evaporation under reduced pressure

出典と根拠

ORDレコード
ord-36348c8524db40d7ba1d0b22bfb36247
出典データセット
uspto-grants-2014_11
特許番号
US08877747B2

反応ノート

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