T5637827 → 3-(4-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one

HRID 331267ノート

反応式

HRID 331267 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:10](=[O:11])[CH2:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 5356382T5637827HCID 6258426(E)-3-(4-fluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one

生成物 1

HCID 703048613-(4-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one収率 47%

実験手順

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(4-fluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one, being stirred for 5 d, and removing TFA by rotary evaporation to obtain the title compound (47%).

後処理

  1. customremoving TFA
  2. customby rotary evaporation

出典と根拠

ORDレコード
ord-eefde60a489b432c9b0a7f32fcc95c8a
出典データセット
uspto-grants-2014_11
特許番号
US08877747B2

反応ノート

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