T5637827 → 3-(3,5-Difluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one

反応式

[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=2)=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[C:11](=[O:12])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

反応物 2

HCID 5356382T5637827

HCID 70311332(E)-3-(3,5-difluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one

生成物 1

HCID 703083363-(3,5-Difluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one収率 99%

実験手順

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(3,5-difluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one and being stirred for 5 d to obtain the title compound (99%).

出典と根拠

ORDレコード: ord-ef42b5f97db24e469edb9ad90acbbdec
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08877747B2

反応ノート

読み込み中…