2-Bromo-3-(2,4-difluorophenyl)-1-oxo-1H-inden-6-yl acetate → 2-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-1H-inden-1-one
反応式
C([O:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[F:23])=[C:10]([Br:15])[C:11]2=[O:14])=[CH:7][CH:6]=1)(=O)C.C(OC1C=C2C(C(C3C=CC=CC=3)=C(Br)C2=O)=CC=1)(=O)C>>[Br:15][C:10]1[C:11](=[O:14])[C:12]2[C:8]([C:9]=1[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[F:23])=[CH:7][CH:6]=[C:5]([OH:4])[CH:13]=2参加物
3
実験手順
The procedure of Step 5 of Example 1 was repeated except for using 2-bromo-3-(2,4-difluorophenyl)-1-oxo-1H-inden-6-yl acetate obtained in Step 4 as a starting material instead of 2-bromo-1-oxo-3-phenyl-1H-inden-6-yl acetate to obtain the title compound (90%).
出典と根拠
- ORDレコード
- ord-4b5a2487634f429c92b90d71b86f4aa8
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877747B2
反応ノート
読み込み中…