Potassium Iodide → tert-Butyl 4-(quinoxalin-2-yl)piperazine-1-carboxylate

HRID 33174ノート

反応式

HRID 33174 の反応式
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C1(C)C=CC=CC=1.O>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:11]=[N:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2389382-Chloroquinoxaline

生成物 1

HCID 25070624tert-Butyl 4-(quinoxalin-2-yl)piperazine-1-carboxylate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

A mixture of 9.1 mmol 2-chloroquinoxaline, 10.0 mmol piperazine-1-carboxylic acid tert-butyl ester, 22.8 mmol potassium carbonate and 2.1 mmol potassium iodide in 20 ml of toluene was refluxed overnight. The reaction mixture was cooled, poured into water and extracted 3 times with ethyl acetate. The organic phase was dried, evaporated and the title compound was crystallised from methanol. Yellowish solid.

後処理

  1. temperaturewas refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted 3 times with ethyl acetate
  4. customThe organic phase was dried
  5. customevaporated
  6. customthe title compound was crystallised from methanol

出典と根拠

ORDレコード
ord-733e9c2c38b94ae1a26504d1d171a4d4
出典データセット
uspto-grants-2008_09
特許番号
US07429585B2

反応ノート

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