HCID 42628942、化合物 → HCID 68445203、化合物

HRID 331776ノート

反応式

HRID 331776 の反応式
[CH:1]([NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2].[CH3:27]C1ON=C(C2C=CC=CC=2)C=1COC1C=CC(C(NC2CCOCC2)=O)=CN=1>>[CH:1]([N:4]([CH3:27])[C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 42628942HCID 42628942、化合物HCID 575200146-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

生成物 1

HCID 68445203HCID 68445203、化合物収率 33%

実験手順

As described for example 50, N-isopropyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide (200 mg, 0.6 mmol), instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide, was converted to the title compound (69 mg, 33%) which was obtained as a colourless gum. MS: m/e=366.3 [M+H]+.

出典と根拠

ORDレコード
ord-ab0abae683e14121ba056128912081c5
出典データセット
uspto-grants-2014_11
特許番号
US08877782B2

反応ノート

読み込み中…