Morpholine → 2-Morpholino-5-nitrobenzoic acid

HRID 33192

反応式

HRID 33192 の反応式
F[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCOCC1>[N:14]1([C:2]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 2809972-Fluoro-5-nitrobenzoic acid

生成物 1

HCID 27257552-Morpholino-5-nitrobenzoic acid収率 93%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 2-fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water, and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in water
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-f733db43a6d34c6ca0de184313a0a727
出典データセット
uspto-grants-2008_09
特許番号
US07429585B2

関連ノート

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