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Methanol → (S)-4-(2-(benzyloxy)ethyl)-2,2,4-trimethyl-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one | HCID 5908088 | — |
| 反応物 | HCID 15956689 | HCID 15956689 | — |
| 生成物 | (S)-4-(2-(benzyloxy)ethyl)-2,2,4-trimethyl-1,3-dioxolane | HCID 67204923 | 81% |
反応手順
To a stirred solution of oxindole 1 (4.19 g, 25 mmol) in methanol (50 mL) was added aldehyde 2 (3.96 g, 25 mmol) and piperidine (2.45 mL, 25 mmol). The reaction mixture was stirred at room temperature for 3 h and the yellow precipitate was collected, washed successively with methanol, hexanes, and ethyl ether and dried to give compound 3 (6.25 g, 81% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877796B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-f7e546787b0b48b78a554e039112702f |
| 出典メモ | uspto-grants-2014_11 |