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Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Magnesium chloride hexahydrate | HCID 24644 | — |
| 反応物 | Vildagliptin | HCID 6918537 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Vildagliptin Magnesium(II)-Chloride | HCID 86675510 | — |
反応手順
0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877799B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-c451687bab2a46079dfc833dbed04ae3 |
| 出典メモ | uspto-grants-2014_11 |