Isopropyl iodide → 4-chloro-N-[5-chloro-2-(isopropylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide

反応式

[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[SH:9].I[CH:11]([CH3:13])[CH3:12].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][C:16]=1[C:25]([F:28])([F:27])[F:26]>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([NH:1][C:2]2[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=2[S:9][CH:11]([CH3:13])[CH3:12])(=[O:23])=[O:22])=[CH:17][C:16]=1[C:25]([F:28])([F:27])[F:26]

参加物

反応物 3

HCID 6362Isopropyl iodide

HCID 120002-Amino-4-chlorobenzenethiol

HCID 27807194-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride

生成物 1

HCID 573783234-chloro-N-[5-chloro-2-(isopropylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide

実験手順

Following General Procedure A and B, the title compound was prepared from 2-amino-4-chloro-benzenethiol, 2-iodo-propane, and 4-chloro-3-(trifluoromethyl)benzene-1-sulfonyl chloride.

出典と根拠

ORDレコード: ord-9528574f1d2a42739c886a68c2570ebd
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08877804B2

反応ノート

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