Hydrochloric Acid → HCID 18934717、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]23[CH2:15][CH2:14][CH2:13][N:12]2[CH2:11][CH2:10][CH2:9]3)[CH:5]=[N:6][CH:7]=1.[ClH:16]>CCOCC>[ClH:16].[CH3:1][C:2]1[CH:3]=[C:4]([C:8]23[CH2:15][CH2:14][CH2:13][N:12]2[CH2:11][CH2:10][CH2:9]3)[CH:5]=[N:6][CH:7]=1参加物
4
実験手順
7a-(5-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine (109 mg, 0.54 mmol) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (112 mg, 87%); mp 153°-154° C.; 1H NMR D2O, 300 MHz) δ2.12-2.49 (m, 9H), 2.57-2.66 (m, 2H), 3.34-3.43 (m, 2H), 3.79-3.87 (m, 2H), 7.90 (s, 1H), 8.46 (s, 1H), 8.52 (s, 1H); MS (CI/NH3) m/z: 203 (M+H)+ ; MS (CI/NH3): m/z 203 (M+H+), 220 (M+NH4+). Anal. Calcd for C13H18N2.1.4 HCl: C, 61.63; H, 7.72; N, 11.06. Found: C, 61.82; H, 7.89; N, 11.00.