化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl Oxalate | HCID 7268 | — |
| 反応物 | 2-Acetylfuran | HCID 14505 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate | HCID 3006753 | — |
反応手順
To a solution of 16 g oxalic acid diethyl ester in 350 ml THF, 10.1 g KOt-Bu were added at 0° C. Then 10 g 1-furan-2-yl-ethanone in 50 ml THF were added dropwise. After 1 h the reaction mixture was diluted with 300 ml ethyl acetate and 200 mnl water. This solution was acidified with diluted hydrochloric acid to pH 5. The organic layer was separated, washed with 150 ml water, dried over MgSO4, filtered and concentrated under reduced pressure to yield a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429581B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-4c8badb3b96b4d3aa4e6dc9d0f230fe0 |
| 出典メモ | uspto-grants-2008_09 |