Hydrochloric Acid → Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate

HRID 33247

反応式

HRID 33247 の反応式
C(O[C:4](=[O:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6])C.CC([O-])(C)C.[K+].[O:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22](=[O:24])[CH3:23].Cl>C1COCC1.C(OCC)(=O)C.O>[CH2:8]([O:7][C:5](=[O:6])[C:4](=[O:10])[CH2:23][C:22]([C:18]1[O:17][CH:21]=[CH:20][CH:19]=1)=[O:24])[CH3:9]

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 7268Diethyl OxalateHCID 145052-AcetylfuranHCID 23665647Potassium tert-butoxide

生成物 1

HCID 3006753Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 16 g oxalic acid diethyl ester in 350 ml THF, 10.1 g KOt-Bu were added at 0° C. Then 10 g 1-furan-2-yl-ethanone in 50 ml THF were added dropwise. After 1 h the reaction mixture was diluted with 300 ml ethyl acetate and 200 mnl water. This solution was acidified with diluted hydrochloric acid to pH 5. The organic layer was separated, washed with 150 ml water, dried over MgSO4, filtered and concentrated under reduced pressure to yield a white solid.

後処理

  1. customThe organic layer was separated
  2. washwashed with 150 ml water
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customto yield a white solid

出典と根拠

ORDレコード
ord-4c8badb3b96b4d3aa4e6dc9d0f230fe0
出典データセット
uspto-grants-2008_09
特許番号
US07429581B2

関連ノート

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