3-(2,5-Difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester → 6-[3-(2,5-Difluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-isopropyl-nicotinamide
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[F:19])=[N:8][O:9][C:10]=1[CH3:11])=O)[CH3:2].C(O[C:23]([C:25]1[C:26](C2C=CC=CC=2F)=[N:27][O:28][C:29]=1C)=O)C>>[F:19][C:13]1[CH:14]=[CH:15][C:16]([F:18])=[CH:17][C:12]=1[C:7]1[C:6]([CH2:4][O:3][C:1]2[CH:2]=[CH:23][C:25]([C:29]([NH:8][CH:7]([CH3:12])[CH3:6])=[O:28])=[CH:26][N:27]=2)=[C:10]([CH3:11])[O:9][N:8]=1参加物
3
実験手順
As described for example 84d, 3-(2,5-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (18 g, 67.4 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (3.25 g, 21%) which was obtained as a yellow oil. MS: m/e=226.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-665c4b01f83f4ec491907b237c69356e