関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isobutanol | HCID 6560 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 2,2-Dimethoxypropanal | HCID 7568181 | — |
| 生成物 | ((1E)-4,4-dimethoxy-3-oxobut-1-en-1-yl)dimethylamine | HCID 5709580 | 48% |
反応手順
A mixture of N,N-dimethylformamide dimethylacetal (86.0 g, 584 mmol) and methylglyoxal 1,1-dimethylacetal (85.6 g, 724 mmol) in isobutanol (500 mL) was heated at 100° C. overnight. The mixture was then cooled and evaporated. Purification by distillation afforded the title product (49.9 g, 48%) as an orange liquid. Bp 123-124° C. at 0.9 mbar. MS: m/e=174.4 [M+H]′.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08877783B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-4b4b5a1a6c3046aeac01f64d054ed011 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
