Hydrochloric Acid → 7a-(5-Bromo-6-fluoro-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride salt

HRID 3326ノート

反応式

HRID 3326 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8].[ClH:17]>CCOCC>[ClH:17].[Br:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 189347337a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

生成物 1

HCID 189347817a-(5-Bromo-6-fluoro-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride salt収率 87%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (59 mg, 87%): mp 213°-215° C.; 1H NMR D2O, 300 MHz) δ2.15-2.49 (m, 6H), 2.56-2.65 (m, 2H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 8.31 (dd, J=2.4, 1.0 Hz, 1H), 8.38 (dd, J=7.8, 2.4 Hz, 1H); MS (CI/NH3) m/z: 285/287 (M+H)+; MS (CI/NH3): m/z 285/287 (M+H+). Anal. Calcd for C12H14BrFN2.HCl: C, 44.81; H, 4.70; N, 8.71. Found: C, 45.04; H, 4.25; N, 8.48.

後処理

  1. customThe solvent was removed
  2. customthe solid was triturated with Et2O
  3. customdried

出典と根拠

ORDレコード
ord-a8c5c25f4fb846a89628f7a3b1c115e3
出典データセット
uspto-grants-1998_03
特許番号
US05733912

反応ノート

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