Water → 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

関与物質

反応手順

To a solution of 2 g 2-(2-Methoxy-ethoxy)-ethanol in 20 ml THF 1.8 g KOt-Bu were added at 0° C. After stirring for 10 min 8.1 ml 3-Bromo-propyne (75% in toluene) were added and the mixture was warmed to RT and stirred for 4 h. Then 10 ml of water were added and the mixture was filtered through a chem elut® cartridge by elution with CHCl3. This solution containing the desired product was subjected to the next reaction step.

情報源と証拠