反応式
[Na].[C:2]([O:12][CH2:13][CH3:14])(=[O:11])[CH2:3][C:4]([C:6](OCC)=[O:7])=O.Cl.[NH2:16][NH2:17]>C(O)C.O.Cl>[CH2:13]([O:12][C:2]([C:3]1[NH:16][N:17]=[C:6]([OH:7])[CH:4]=1)=[O:11])[CH3:14]参加物
6
反応条件
- 温度
- 80 °C
実験手順
To a solution of 5 g Diethyl Oxalacetate sodium salt in 100 ml ethanol, 1.5 g hydrazine monohydrochloride were added and the reaction mixture was heated to 80° C. for 3 h. Then the solution was diluted with 100 ml of water containing 3 ml of halfconcentrated HCl and extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was subjected to the next reaction step without further purification; Yield: 3.4 g
後処理
- extractionextracted with DCM (3×100 ml)
- dry with materialThe combined organic layers were dried over MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customThe crude product was subjected to the next reaction step without further purification
出典と根拠
- ORDレコード
- ord-1eaec0aabaf74bf68499db6ce002e679
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429581B2
関連ノート
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