Hydrochloric Acid → HCID 18934769、化合物

HRID 3328

反応式

HRID 3328 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8].Cl>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 189347597a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

生成物 1

HCID 18934769HCID 18934769、化合物収率 74%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (35 mg, 74%): mp 181°-183° C.; 1H NMR (D2O, 300 MHz) δ2.15-2.50 (m, 6H), 2.56-2.65 2H), 3.34-3.42 (m, 2H), 3.79-3.87 (m, 2H), 8.24-8.29 (m, 2H); MS (CI/NH3) m/z: 241 (M+H)+ ; MS (CI/NH3): m/z 241/243 (M+H+). Anal. Calcd for C12H14 ClFN2.HCl: C, 52.00; H, 5.45; N, 10.11. Found: C, 51.81; H, 5.62; N, 9.84.

後処理

  1. customThe solvent was removed
  2. customthe solid was triturated with Et2O
  3. customdried

出典と根拠

ORDレコード
ord-de9abf64e74b42648268c346ed5db6f3
出典データセット
uspto-grants-1998_03
特許番号
US05733912

関連ノート

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