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HRID 33300作成日：2026年10月25日

(4-Bromophenyl)boronic acid → 2-(4-Bromophenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

https://huagongshe.com/reaction/33300

反応式

関与物質

役割名称HCID仕込み量
反応物(4-Bromophenyl)boronic acidHCID 79599—
反応物2-Iodo-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-oneHCID 9883223—
反応物2-Phenyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-oneHCID 10220882—
生成物2-(4-Bromophenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-oneHCID 22266670—

反応手順

In a manner similar to that described for Compound 12, 2-iodo-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one (85 mg, 0.28 mmol; see Example NN below) and 4-bromophenylboronic acid (62 mg, 0.31 mmol) were coupled to yield 2-(4-bromophenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one, 19 mg (20%), as a white solid. mp 160° C. (dec.); 1H NMR (300 MHz, d6-DMSO) δ 3.04 (m, 2H), 3.39 (m, 2H), 7.23 (app t, 1H, J=7.5 Hz), 7.56 (dd, 1H, J=8.1, 0.9 Hz), 7.60 (d, 2H, J=8.7 Hz), 7.69 (dd, 1H, J=7.5, 0.6 Hz), 7.73 (d, 2H, J=8.4 Hz), 8.09 (br t, 1H), 11.64 (br s, 1H); MS (FAB, MH+) 341/343; Anal. (C17H13BrN2O. 0.6 H2O) C, H, N.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07429578B2
出典データセットuspto-grants-2008_09
ORD IDord-5593bb940d81459985ce589e0e864214
出典メモuspto-grants-2008_09