7-Hydroxy-4-benzopyrone → Chroman-7-ol

HRID 333039

反応式

HRID 333039 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[CH:7]=[CH:8][O:9]2)=[CH:4][CH:3]=1.[H][H]>[C].[Pd].C(O)C>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][O:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 54092797-Hydroxy-4-benzopyroneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 12236542Chroman-7-ol収率 95%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a 1000 mL round bottomed flask, 0.15 mol of 7-hydroxychromone, and then 2.50 g of 5% palladium carbon and 300 mL of ethanol were added. Subsequently, hydrogen was passed into the flask, and the reaction was carried out for 48 hours at 50° C. Palladium carbon was removed by sucking filtration, and ethanol was removed by rotary evaporation. Then 21.39 g of 7-hydroxychroman was obtained, with a yield of 92.4% and MS m/z (M)150.

後処理

  1. customPalladium carbon was removed
  2. filtrationfiltration, and ethanol
  3. customwas removed by rotary evaporation

出典と根拠

ORDレコード
ord-d74c087b0fb84a85bc5ff7065147cb01
出典データセット
uspto-grants-2014_11
特許番号
US08877949B2

関連ノート

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