関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Methoxy-2-propanol | HCID 7900 | — |
| 反応物 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 反応物 | 4-Chloro-2-methylquinoline | HCID 77973 | — |
| 生成物 | N,N'-Dimethyl-N-(2-methyl-4-quinolyl)ethane-1,2-diamine | HCID 62593346 | — |
反応手順
4-Chloroquinaldine (1.5 g, 5 mmol) was mixed with N,N′-dimethylethylenediamine (2.45 ml, 25 mmol) and 1-methoxy-2-propanol (8 ml) and stirred at 110° C. overnight. The mixture was purified by column chromatography (pre-packed silica column, gradient of heptane/ethyl acetate each containing 1% triethylamine). 0.4 g were obtained (1.75 mmol; 35%). MS (APCI) m/z=230.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08877934B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-a4a93f8d61484b439d763712b480ab17 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
