2,4-Dichloroquinoline → 4-Chloro-2-methoxyquinoline

HRID 333054

反応式

HRID 333054 の反応式
Cl[C:2]1[CH:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([O:14][CH3:13])[CH:11]=1

参加物

4

反応物 2

HCID 6075032,4-DichloroquinolineHCID 10942334Sodium Methoxide

生成物 1

HCID 109653774-Chloro-2-methoxyquinoline収率 86%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a solution of (2.5 g, 12.6 mmol) 2,4-dichloro-quinoline in anhydrous toluene (20 ml) was added a suspension of solid sodium methoxide (2.5 g, 46.3 mmol) in anhydrous toluene (20 ml). The mixture was stirred under reflux for 16 hours and then allowed to cool to room temperature. The solid that had formed was filtered off and washed with 50 ml toluene. The filtrate was evaporated to dryness under reduced pressure to yield a red solid (2.1 g, 10.8 mmol, 86%). MS (ES) m/z=193.1 [M+H]+.

後処理

  1. temperatureunder reflux for 16 hours
  2. customThe solid that had formed
  3. filtrationwas filtered off
  4. washwashed with 50 ml toluene
  5. customThe filtrate was evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-48e1dd726a364dd0af1d0b5699513a2f
出典データセット
uspto-grants-2014_11
特許番号
US08877934B2

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