Hydrochloric Acid → N2-(2,6-Dimethyl-4-pyridyl)propane-1,2-diamine hydrochloride
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][CH:9]([CH3:19])[CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[C:4]([CH3:20])[N:3]=1.[ClH:21]>O1CCOCC1>[ClH:21].[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][CH:9]([CH3:19])[CH2:10][NH2:11])[CH:5]=[C:4]([CH3:20])[N:3]=1参加物
4
実験手順
To tert-butyl 2-(2,6-dimethylpyridin-4-ylamino)propylcarbamate (147 mg, 0.526 mmol) dissolved in 1,4-dioxane (1 ml) a 4N solution of HCl in dioxane (2 ml, 8.00 mmol) was added. Within a few minutes a precipitate started to form. The solvent was removed in a stream of nitrogen, to the residue was added diethylether and the mixture was allowed to stand at room temperature overnight. The solvent was filtered off, the residue was dried under reduced pressure to yield 135 mg of an off-white solid MS (ESI) m/z=180.0.
後処理
- additionwas added
- waitWithin a few minutes a precipitate started
- customto form
- customThe solvent was removed in a stream of nitrogen, to the residue
- additionwas added diethylether
- filtrationThe solvent was filtered off
- customthe residue was dried under reduced pressure
出典と根拠
- ORDレコード
- ord-23b3de78bbb24b248281e8b8438fb5c3
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877934B2
反応ノート
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