Dimethylamine → (1-(4-fluorophenyl)cyclohexyl)-N,N-dimethylmethanamine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14](O)=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][NH:18][CH3:19]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:14][N:18]([CH3:19])[CH3:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
The title compound was synthesized from 1-(4-fluorophenyl)cyclohexane-carboxylic acid and dimethyl amine using General Procedure G, followed by General Procedure E in 9% yield as a solid. LCMS Rt=7.22 min, m/z=236 (M+1). 1H NMR (CDCl3, δ): 7.32 (dd, J=5.5, 8.9 Hz, 2H), 6.99 (t, J=8.8 Hz, 2H), 2.30 (s, 2H), 2.1 (m, 2H), 1.97, (s, 6H), 1.7-1.3 (m, 8H. 13C NMR (CDCl3, δ, mult): 162.0(0), 159.6(0), 141.7(0), 128.8(1), 128.7(1), 114.7(1), 114.5(1), 72.9(2), 56.5(0), 48.4(3), 34.3(2), 26.6(2), 22.1(2).
出典と根拠
- ORDレコード
- ord-8b8ffd320eba40c987f8087cb1464d52
- 出典データセット
- uspto-grants-2014_11