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1,5-Dibromopentane → 1-[3-(Trifluoromethyl)phenyl]cyclohexane-1-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,5-Dibromopentane | HCID 8100 | — |
| 反応物 | m-Trifluoromethylphenylacetonitrile | HCID 75360 | — |
| 生成物 | 1-[3-(Trifluoromethyl)phenyl]cyclohexane-1-carbonitrile | HCID 28937684 | 96% |
反応手順
The title compound was prepared from 2-(3-(trifluoromethyl)phenyl)acetonitrile (3.463 ml, 22.2 mmol) and 1,5-dibromopentane (3.324 ml, 24.4 mmol) according to General Procedure J to yield 1-(3-(trifluoromethyl)phenyl)cyclohexane-carbonitrile (5.40 g, 90%) as a clear oil. 1H NMR (CDCl3) δ 1.26-1.39 (m, 1H), 1.76-1.88 (m, 7H), 2.17 (d, J=11.2 Hz, 2H), 7.51-7.60 (m, 3H), 7.73 (s, 1H). 13C NMR (CDCl3) δ 23.7, 25.0, 37.5, 44.6, 122.5, 125.0, 125.1, 126.0, 129.5, 130.0, 142.8,GC-MS m/z 253.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877975B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-3676b69b7c4d406d84722d393006e827 |
| 出典メモ | uspto-grants-2014_11 |