Trifluoroacetic acid methylene chloride → 4-Ethoxycarbonyl-4-ethylpiperidine trifluoroacetate

HRID 333428ノート

反応式

HRID 333428 の反応式
[CH2:1]([C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)[CH3:2].ClCCl.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[CH2:19]([O:18][C:16]([C:3]1([CH2:1][CH3:2])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=[O:17])[CH3:20]

参加物

3

反応物 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 53393415Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

生成物 1

HCID 669880094-Ethoxycarbonyl-4-ethylpiperidine trifluoroacetate収率 73%

実験手順

183 mg (0.64 mmol) of tert-butyl 4-ethyl-4-ethoxycarbonylpiperidine-1-carboxylate are diluted in 4 mL of an 8/2 dichloromethane/trifluoroacetic acid mixture. The solution is stirred at room temperature for 1 hour and the solvents are then evaporated off. 140 mg of 4-ethoxycarbonyl-4-ethylpiperidine trifluoroacetate in the form of an oil are obtained in a yield of 73%.

後処理

  1. customthe solvents are then evaporated off

出典と根拠

ORDレコード
ord-d40fb2bcff7d4674b1093f8ed8aae5a9
出典データセット
uspto-grants-2014_11
特許番号
US08877968B2

反応ノート

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