Dichloromethane → N-(6-Cyanohexanoyl)glycine, ethyl ester

HRID 3335

反応式

HRID 3335 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8].[C-:16]#[N:17].[K+].ClCCl>C(O)C>[C:16]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8])#[N:17]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 9032Potassium CyanideHCID 86154941N-(6-bromohexanoyl)-glycine, ethyl ester

生成物 1

HCID 85707690N-(6-Cyanohexanoyl)glycine, ethyl ester収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

23.73 g (84.7·10-3 mol) of N-(6-bromohexanoyl)-glycine, ethyl ester are dissolved in 200 ml of ethanol, and 6.5 g (0.1 mol) of powdered potassium cyanide are added. The reaction mixture is brought to the reflux point and stirred under reflux for 15 hours. After concentration of the mixture under reduced pressure, the residue is taken up with dichloromethane and the organic phase is washed with aqueous sodium chloride solution. The organic phase is dried and concentrated under reduced pressure to give 19 g of the expected product (yield=99%).

後処理

  1. temperatureunder reflux for 15 hours
  2. washthe organic phase is washed with aqueous sodium chloride solution
  3. customThe organic phase is dried
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f0e0f1638dcd40c780aa7d8ec6375945
出典データセット
uspto-grants-1998_03
特許番号
US05733928

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