Dextromethorphan Hydrobromide → Dextromethorphan

温度

77.5 °C

The Dextromethorphan Resin Complex was prepared by first dissolving 954 g of dextromethorphan HBr in 8 liters of purified water heated to 75-80° C., and then slowly adding 1,758 g of AMBERLITE™ IRP-69 resin with continuous mixing while cooling down to room temperature. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 20-25%. In a separate container, KOLLIDON K-30 polymer (116 g) was dissolved in 1,150 g of purified water and slowly applied to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was then dried at 50° C. in a VWR™ convection oven to the moisture content was around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 1,758 g of AMBERLITE™
2. additionresin with continuous mixing
3. temperaturewhile cooling down to room temperature
4. additionThe dispersion was mixed for 4 hours and upon completion
5. custombefore decanting the supernatant
6. customThe wet resin complex was then dried in a VWR™ convection oven
7. temperaturemaintained at 50° C. until moisture content
8. dissolutionIn a separate container, KOLLIDON K-30 polymer (116 g) was dissolved in 1,150 g of purified water
9. customto form a uniform mass
10. customThe wet mass was then dried at 50° C. in a VWR™ convection oven to the moisture content
11. customThe dried granules were then milled through a 40 mesh screen

ORDレコード

ord-63b39d2f6cb44373bc48062043d99df2

出典データセット

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08883217B2