Methylamine → HCID 68205821、化合物

反応式

Cl[C:2]1[C:3]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:15][NH2:16]>>[CH3:15][NH:16][C:2]1[C:3]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][N:7]=1

参加物

反応物 2

HCID 6329Methylamine

HCID 61699136HCID 61699136、化合物

生成物 1

HCID 68205821HCID 68205821、化合物収率 57.3%

実験手順

3-chloro-N-phenylpyrazin-2-amine (4.5 g, 21.22 mmol) was stirred with methyl amine (20.59 g, 20.9 mmol, 33 wt % in THF) under reflux overnight. The solvent was evaporated and the residue was purified by column chromatography using 50% ethyl acetate and hexanes to give N2-methyl-N3-phenylpyrazine-2,3-diamine (2.4 g, 54.8%).

後処理

temperatureunder reflux overnight
customThe solvent was evaporated
customthe residue was purified by column chromatography

出典と根拠

ORDレコード: ord-3981719619e14fde80b5daa7b997ebc8
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08883322B2

反応ノート

読み込み中…

参加物