Aniline → 3-nitro-N-phenylpyridin-2-amine

HRID 333535ノート

反応式

HRID 333535 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N(CC)CC)C>C(O)CCC>[N+:8]([C:7]1[C:2]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

参加物

5

反応物 3

HCID 6115AnilineHCID 8471TriethylamineHCID 796132-Chloro-3-nitropyridine

生成物 1

HCID 6117993-nitro-N-phenylpyridin-2-amine収率 85.3%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

2-chloro-3-nitropyridine (25 g, 158 mmol), aniline (17.62 g, 189 mmol), and triethylamine (19.15 g, 189 mmol) were mixed in 1-butanol (500 mL). The reaction was heated to reflux overnight. After it cooled to room temperature, the solvent was distilled. The residue was purified by column chromatography using hexanes/ethyl acetate to give 3-nitro-N-phenylpyridin-2-amine (29 g, 85% yield).

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. distillationthe solvent was distilled
  4. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-a73a65a7ac94418eaa2c4299ee2effe2
出典データセット
uspto-grants-2014_11
特許番号
US08883322B2

反応ノート

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