Ethanol → 2-Ethylamino-3-nitropyridine
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12].C(O)C>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]参加物
4
実験手順
2-Chloro-3-nitropyridine (20.00 g, 126 mmol) was added to ethylamine in ethanol (40 mL, 80 mmol) at room temperature and kept overnight. The solution was evaporated, the residue was diluted with 150 mL of EtOAc, washed with aqueous NaHCO3 and purified by column chromatography on silica gel (hexane/ethyl acetate 4/1) to give yellow solid (19.5 g, 92%).
後処理
- customThe solution was evaporated
- additionthe residue was diluted with 150 mL of EtOAc
- washwashed with aqueous NaHCO3
- custompurified by column chromatography on silica gel (hexane/ethyl acetate 4/1)
出典と根拠
- ORDレコード
- ord-73ac23f5c8694659b3474991d37be063
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883322B2
反応ノート
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