Hydrochloric Acid → HCID 178462804、化合物

HRID 333552ノート

反応式

HRID 333552 の反応式
[CH2:1]([NH:3][C:4]1[C:9]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)C.[ClH:17].C(O[CH2:26][CH3:27])(OCC)OCC>C(O)=O>[Cl:17][N+:3]1([CH2:26][CH3:27])[C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH-:1]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31214Ethyl orthoformateHCID 70665410HCID 70665410、化合物

生成物 1

HCID 178462804HCID 178462804、化合物収率 91%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

N2-ethyl-N3-phenylpyridine-2,3-diamine (8.5 g, 40 mmol), concentrated HCl (6 mL), and 4 mL of formic acid were added to the triethyl orthoformate (376 mL). The reaction was refluxed overnight. After it cooled to room temperature, the beige solid was collected by filtration. The solid was further purified by recrystallizing from ethanol to give 3-chloro-3-ethyl-1-phenyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-3-ium-2-ide (9.4 g, 91% yield).

後処理

  1. temperatureThe reaction was refluxed overnight
  2. filtrationthe beige solid was collected by filtration
  3. customThe solid was further purified
  4. customby recrystallizing from ethanol

出典と根拠

ORDレコード
ord-e6aa036cc27a441ca968d25f2050ce80
出典データセット
uspto-grants-2014_11
特許番号
US08883322B2

反応ノート

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