Methylamine → 3-Iodo-N-methylpyridin-2-amine
反応式
F[C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:9][NH2:10]>>[I:8][C:7]1[C:2]([NH:10][CH3:9])=[N:3][CH:4]=[CH:5][CH:6]=1参加物
3
実験手順
A 1 L round bottom flask was charged with 2-fluoro-3-iodopyridine (27.0 g, 121 mmol) and 500 mL of 40% aqueous solution of methylamine. This was stirred at reflux for 4 h before being cooled to ambient temperature. The product was extracted with dichloromethane. Evaporation of the dichloromethane gave 3-iodo-N-methylpyridin-2-amine (26.8 g, 95% yield).
後処理
- temperatureat reflux for 4 h
- extractionThe product was extracted with dichloromethane
- customEvaporation of the dichloromethane
出典と根拠
- ORDレコード
- ord-a99fea72260e4f50968c688851281af9
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883322B2
反応ノート
読み込み中…