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Potassium Carbonate → Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | tert-butyl N-(3-amino-3-methylbutyl)carbamate | HCID 45072486 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate | HCID 86603965 | — |
反応手順
2.0 g (12.9 mmol) 3-fluoro-4-nitro-toluene, 2.6 g (13.0 mmol) tert-butyl (3-amino-3-methyl-butyl)-carbamate and 2.3 g (16.8 mmol) potassium carbonate are stirred overnight at ambient temperature in 20 mL DMF. The solvent is distilled off and the residue is combined with ethyl acetate. The mixture is washed repeatedly with water, dried with sodium sulphate and the solvent is eliminated. 4.8 g yellow oil. Mass spectroscopy: [M+H]+=338.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429583B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-0f0c11cfd1dc4952bf8cc9718579b0c3 |
| 出典メモ | uspto-grants-2008_09 |